Gene therapy for human cancer: an essay for clinicians. - PubMed

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Create File/>/>/>/>/>/>/>/>/>/>/>/>/>/>/>/> />/> Semin Oncol. 1996 Feb;23(1):4-21.

Gene treatment for individual cancer: an essay for clinicians.

Mastrangelo MJ1, Berd D, Nathan FE, Lattime EC.

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1Department of Medicine, Jefferson health College, Philadelphia, Pennsylvania, USA.

Abstract

In the last ten years our understanding of the procedures that govern development and differentiation has become quite sophisticated. Many different tumor suppressor genes and much more than 100 oncogenes have now been identified. The functions of developmental genes in shaping the expression of neoplasia and of defective housekeeping genes in enabling mutations to persist and start to become transcribed are valued. These improvements have actually revolutionized our capability to diagnose and also to formulate prognoses for clients with cancer tumors. However, successful gene treatment for cancer tumors happens to be elusive. This review highlights the existing ways to gene therapy for cancer and their medical bases. The necessity that the treatment repair or destroy every cancer cellular appears an insurmountable hurdle. Environmental manipulation through systemic management of exogenous antisense may circumvent this issue in cases where its appropriate. The greater program regarding the technology of hereditary engineering to facilitate cancer tumors chemotherapy and immunotherapy can be reviewed. Specially encouraging are the preclinical and clinical outcomes of in vivo, in situ gene transfer. It remains to be determined if this regional approach impacts positively on survival.

PMID: 8607031 [Indexed for MEDLINE]

Publication type, MeSH terms

Publication type

  • Review

MeSH terms

  • Gene Transfer Techniques
  • Genes, Suppressor
  • Genetic Engineering
  • Genetic Therapy*
  • Humans
  • Neoplasms/genetics
  • Neoplasms/therapy*
  • Oncogenes

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